임상병리학과

고려대학교(생물공학) 학사
연세대학교(생화학) 석사
The Pennsylvania State University(세포생물학) 박사

미국 존스홉킨스의과대학교 피부과, 박사후연구원(Post-doc)

1. 연구과제
1) Stem cell clinical trial for conversion of stump skin to palmo-plantar type skin as a means of enhancing prosthetic use (Department of Defense, USA) (2014 – 2019 )
2) Testing fibroblasts stem cell to convert skin identity (2017-MSCRFF-3905; Maryland Stem Cell Research Funds, USA) (2017 – 2019 )
3) 엑소좀 (exosome)의 생합성 및 조직재생능에 미치는 TLR3 활성화 기전 연구 (이공분야 기초연구사업-신진연구) (2020 – 2024 )
4) Toll Like Receptor 3 (TLR3) 활성화를 통한 피부 및 모발재생 유도제 개발 (실험실창업지원사업) (2021)
5) 맞춤형화장품 자동조제기 카트리지용 화장품 원료 개발 (지산학협력 기업 R&D 지원사업) (2023)

2. 연구논문
1) The use of ectopic volar fibroblasts to modify skin identity. Science. 2024; 385(6713):eadi1650 (Co-author)
2) Lagerstroemia macrocarpa extract inhibits Th2-mediated STAT6 signaling pathway in human keratinocytes. Fitoterapia. 2024;174:105859 (Corresponding author)
3) Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3. Kim D†, Chen R, Sheu M, Kim N, Kim S, Islam N, Wier EM, Wang G, Li A, Park A, Son W, Evans B, Yu V, Prizmic VP, Oh E, Wang Z, Yu J, Huang W, Archer NK, Hu Z, Clemetson N, Nelson AM, Chien A, Okoye GA, Miller LS, Chiaur G, Kang S, Jones JW, Kane MA, Garza LA†. Nature Communications 2019; 10(1): 2811-2824. (†First author and Co-corresponding author)
4) Reversine enhances skin barrier functions by suppressing the IL-4 and IL-13-mediated STAT6 pathway. Journal of Dermatological Science. 2023; 111(2):71-73 (Corresponding author)
5) Novel Quinazoline derivatives induces differentiation of keratinocytes and enhances skin barrier functions against Th2 cytokine-mediated signaling. Molecules. 2023; 28(16):6119 (Corresponding author)
6) Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1a signaling and glutamine metabolism. Science Advances. 2023; 9(1):eabo7555 (Co-author)
7) CD14 is induced by retinoic acid and is required for double stranded noncoding RNA-induced regeneration. Journal of Investigative Dermatology. 2022; 142(8):2201-2294 (First author)
8) GC-TOF/MS-based metabolomics for comparison of volar and non-volar skin types. Metabolites. 2022; 12(8):717 (Corresponding author)
9) Simple cell culture media expansion of primary mouse keratinocytes. Kim S, Kim BW, Prizmic VP, Oh E, Yu V, Kim D†, Garza LA†. J Dermatol Sci. 2019;93(2):135-138. (†Co-corresponding author)
10) dsRNA sensing induces loss of cell identity. Zhou R*, Wang G*, Kim D*, Kim S, Islam N, Garza LA. J Invest Dermatol 2019; 139(1):91-99. (*Co-first author)
11) TLR3 activation links tissue damage to epimorphic regeneration in the skin. Nelson AM, Reddy SK, Ratliff TS, Zhu AS, Hossain MZ, Kateseff AS, Chang E, Resnik SR, Page C, Kim D, Whittam AJ, Miller LS, Garza LA. Cell Stem Cell 2015; 17(2):139-51. (Co-author)
12) To control site-specific skin gene expression, autocrine mimics paracrine canonical Wnt signaling and is activated ectopically in skin disease. American Journal of Pathology 2016; 186(5):1140-50. (First author)

고려대학교(생물학), 학사
고려대학교(동물학), 석사
고려대학교(동물학), 박사

동서대학교 보건의료계열 학부장
동서대학교 보건의료계열 임상병리학과 책임교수
경희대학교 연구전임강사
고려대학교 연구조교수
제일약품 주식회사 신약연구실 책임연구원

* 논문

주요우울장애의 발병률에 미치는 성의 영향, 스트레스연구, 21, 167-174, 2013

Neuroprotective Effects of α-Tocotrienol on Kainic Acid-Induced Neurotoxicity in Organotypic Hippocampal Slice Cultures, International Journal of Molecular Sciences, 14, 18256-18268, 2013

주요우울장애와 생물표지자, 스트레스연구, 20, 247-255, 2012

혈소판의 기능 측정방법과 그 활용, 응용미약에너지학회지, 10, 1-4, 2012

Effects of Electroacupuncture at BL60 on Formalin-Induced Pain in Rats, Evidence-Based Complementary and Alternative Medicine, 2012, 797-807, 2012

Coenzyme Q10 protects neurons against neurotoxicity in hippocampal slice culture, Neuroreport, 22, 96-107, 2011

Optical imaging of somatosensory evoked potentials in the rat cerebral cortex after spinal cord injury, Journal of Neurotrauma, 28, 1-5, 2011

Inhibition of hexokinase leads to neuroprotection against excitotoxicity in organotypic hippocampal slice culture, Journal of Neuroscience Research, 89, 551-558, 2011

Neuroprotective effects of FK506 against excitotoxicity in organotypic hippocampal slice culture, Neuroscience Letters, 474, 126-130, 2010

통증, 침술 및 뇌영상, 감성과학, 13, 551-558, 2010

신경병리성 동통과 교차-철회 반사, 응용미약자기에너지학회지, 7, 22-26, 2009

Relationship between diet composition and the fecundity of Musca domestica, Entomological Research, 39, 412-415, 2009

Reproducibility and desensitization of the power frequency magnetic field effect
on movement of the common cutworm Spodoptera litura, Entomological Research, 39, 406-409, 2009

Cloning and blood-meal dependent induction pattern of apolipophorin-III from Anopheles sinensis, Entomological Research, 39, 388-393, 2009

Modulation of Neuropathic Pain by Galanin and Neuropeptide Y at the Level of
the Medulla in Rats, International Journal of Neuroscience, 119, 1941-1955, 2009

Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures, Can. J. Physiol. Pharmacol, 87, 440-447, 2009

Anti-oxidant effet of ascorbic and dehydroascorbic acids in hippocalmpal slice culture, Biochemical and Biophysical Research Communications, 366, 8-14, 2008

고려대학교 생물학과 학사
고려대학교 생명공학과(분자미생물학) 석사
고려대학교 생명공학과(분자미생물학) 박사

미국 코넬대학교 미생물학과, 선임연구원(Research Associate)
미국 코넬대학교 미생물학과, 박사후연구원(Post-doc)
고려대학교 BK21생명공학원사업단 연구교수
세종대학교 생명공학과 강사
서울대학교 의과대학 암연구소(면역학) 연구원

-연구논문

Kim S, Lee YH. The Salmonella enterica EnvE is an Outer Membrane Lipoprotein and Its Gene Expression Leads to Transcriptional Repression of the Virulence Gene msgA. J Microbiol. 2024;62(11):1013-1022.

Kim S, Lee YH. Impact of small RNA RaoN on nitrosative-oxidative stress resistance and virulence of Salmonella enterica serovar Typhimurium. J Microbiol. 2020;58(6):499-506.

Lee YH, Kim JH. Direct interaction between the transcription factors CadC and OmpR involved in the acid stress response of Salmonella enterica. J Microbiol. 2017;55(12):966-972.

Kim BM, Hong Y, Lee S, Liu P, Lim JH, Lee YH, Lee TH, Chang KT, Hong Y. Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy. Int J Mol Sci. 2015;16(11):26880-26913.

Lee YH, Helmann JD. Mutations in the primary sigma factor σA and termination factor rho that reduce susceptibility to cell wall antibiotics. J Bacteriol. 2014;196(21):3700-3711.

Lee YH, Helmann JD. Reducing the Level of Undecaprenyl Pyrophosphate Synthase Has Complex Effects on Susceptibility to Cell Wall Antibiotics. Antimicrob Agents Chemother. 2013;57(9):4267-4275.

Lee YH, Kim S, Helmann JD, Kim BH, Park YK. RaoN, a small RNA encoded within Salmonella pathogenicity island-11, confers resistance to macrophage-induced stress. Microbiology(SGM). 2013;159(Pt 7):1366-1378.

Lee YH, Nam KH, Helmann JD. A mutation of the RNA polymerase β' subunit (rpoC) confers cephalosporin resistance in Bacillus subtilis. Antimicrob Agents Chemother. 2013;57(1):56-65.

Lee YH, Kim S, Kim JH, Bang IS, Lee IS, Bang SH, Park YK. A phosphotransferase system permease is a novel component of CadC signaling in Salmonella enterica. FEMS Microbiol Lett. 2013;338(1):54-61.

Lee YH, Kingston AW, Helmann JD. Glutamate dehydrogenase affects resistance to cell wall antibiotics in Bacillus subtilis. J Bacteriol. 2012;194(5):993-1001.

을지대학교 임상병리학과 학사
을지대학교 시니어헬스케어학과(임상병리학) 석사
을지대학교 시니어헬스케어학과(임상병리학) 박사

대구보건대학교 임상병리학과 조교수
세종충남대학교병원 미래의학연구원 보건직
충남대학교병원 인체자원은행 연구원
KAIST 세포벤치연구센터 연구원
대한임상병리사협회 정회원
대한임상병리사협회 대구시회 교육이사
대한의생명과학회 학술부위원장

1. Polysaccharide Hydrogel-Assisted Biosensing Platforms for Point-of-Care Use, Biosensors 2025, 15(1), 13
2. Carcinoembryonic antigen positive circulating epithelial cells as a biomarker for the diagnosis and prognosis of colorectalcancer, Biotechnology and Bioprocess Engineering, 2024; 29(5): 877-889
3. Programmed Death 1 and Cytotoxic T-Lymphocyte Associated Protein 4 Gene Expression in Peripheral Blood Mononuclear Cells Can Serve as Prognostic Biomarkers for Hepatocellular Carcinoma, Cancers, 2024 Apr 13;16(8):1493
4. Machine-Learning-Based Clinical Biomarker Using Cell-Free DNA for Hepatocellular Carcinoma (HCC), Cancers (Basel), 2022 Apr 20;14(9):2061
5. Fabrication of Formalin-Fixed, Paraffin-Embedded (FFPE) Circulating Tumor Cell (CTC) Block Using a Hydrogel Core-Mediated Method. Micromachines (Basel). 2021 Sep 20;12(9):1128.
6. Tri-modal liquid biopsy: Combinational analysis of circulating tumor cells, exosomes, and cell-free DNA using machine learning algorithm. Clin Trans Med. 2021 Aug;11(8):e499.
7. The specific gravity-free method for the isolation of circulating tumor KRAS mutant DNA and Exosome in colorectal cancer. Micromachines 2021, 12(8), 987.
8. Enhanced detection of cell-free DNA (cfDNA) enables its use as a reliable biomarker for diagnosis and prognosis of gastric cancer, PLoS One, 2020 Dec 2;15(12):e0242145.
9. Identification of a Clinical Cutoff Value for Multiplex KRASG12/G13 Mutation Detection in Colorectal Adenocarcinoma Patients Using Digital Droplet PCR, and Comparison with Sanger Sequencing and PNA Clamping Assay. J Clin Med. 2020 Jul 18;9(7):2283.
10. Prognostic Significance of LC3B and p62/SQSTM1 Expression in Gastric Adenocarcinoma. Anticancer Res. 2019 Dec;39(12):6711-6722.
11. Multi-modal liquid biopsy platform for cancer screening: screening both cancer-associated rare cells and cancer cell-derived vesicles on the fabric filters for a reliable liquid biopsy analysis. Nano Converg. 2019 Nov 15;6(1):39.
12. Clinical significance of atypical protein kinase C (PKCι and PKCζ) and its relationship with yes-associated protein in lung adenocarcinoma. BMC Cancer. 2019 Aug 14;19(1):804.
13. Sub-lethal hyperthermia promotes epithelial-to-mesenchymal-like transition of breast cancer cells: implication of the synergy between hyperthermia and chemotherapy. RSC Advances 9 (2019): 52-57.
14. Cytopathological Study of the Circulating Tumor Cells filtered from the Cancer Patients’ Blood using Hydrogel-based Cell Block Formation, Scientific Reports 8 (2018)
15. A multi-staining chip using hydrophobic valves for exfoliative cytology in cancer, Journal of Micromechanics and Microengineering, 27 (2017) 075022.
16. Polyester fabric sheet layers functionalized with graphene oxide for sensitive isolation of circulating tumor cells. Biomaterials. 2017 May;125:1-11.
17. Microfluidic-based mechanical phenotyping of cells for the validation of epithelial-to-mesenchymal-like transition caused by insufficient heat treatment. Sensors and Actuators B-chemical 244 (2017): 591-598.

알지네이트-폴리도파민-실리카 복합체를 포함하는 세포 유리(cell free) DNA 추출용 조성물
알지네이트 비드 매개의 세포절편 제작방법
알지네이트와 PVA 복합비드를 매개로 하는 세포절편 제작방법
알긴산을 이용한 특정세포와 엑소좀 동시 분리방법

마산대학교 전문학사,
한국방송통신대학교 생활과학부 가정학사,
부경대학교 산업미생물학과 이학석사 ,
동아대학교국제법무학과 박사

일신기독병원 진단검사의학과 / 의료질 향상실
마산대학교 임상병리과 겸임교수
김해대학대학교 임상병리과 겸임교수
동의과학대학교 임상병리과 겸임교수
부산임상병리사협회 학술 교육이사
부산임상병리사협회 행정 법제이사
임상화학 전문임상병리사

ㆍ부산가톨릭대학교(임상병리학), 학사
ㆍ부산가톨릭대학교(임상병리학), 석사
ㆍ동아대학교 의학과(병리학), 박사

ㆍ부산가톨릭대학교 임상병리학과 학사조교
ㆍ동아대학교 의과대학 병리학교실 전임연구원
ㆍ동의대학교 임상병리학과 강사
ㆍ동서대학교 임상병리학과 강사

1. Potential ameliorative effects of anion generator in rat with adjuvant-induced arthritis. The Asian International Journal of Life Sciences. 2014;10:75-87.
2. The Effect of Berchemia berchemiaefolia Extract in a Rat Model Acetic Acid-induced Irritable Bowel Syndrome. International Journal of Bio-Science and Bio-Technology. 2014;.6(5):67-82.
3. DNA ligase4 as a prognostic marker in nasopharyngeal cancer patients treated with radiotherapy. Asian Pac J Cancer Prev. 2014;15(24):10985-9.
4. Targeted anticancer effect through microRNA-181a regulated tumor-specific hTERT replacement. Cancer Lett. 2015;356(2 Pt B):918-28.
5. The Influence of Korean Berchemia berchemiaefolia (Makino) Koidz Extract on Nonalcoholic Hepatic Steatosis in Rats. Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology. 2015;5(3):131-142.
6. Targeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA Regulation. Sci Rep. 2015;5:12315.
7. By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, stichoposide D inhibits growth of leukemia xenografts. Oncotarget. 2015;6(29):27596-612.
8. Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma. Theranostics. 2016;6(3):357-68.
9. Clinicopathologic significance of tumor microenvironment CD11c, and FOXP3 expression in diffuse large B-cell lymphoma patients receiving rituximab, cyclophosphamide, anthracycline, vincristine, and prednisone (R-CHOP) combination chemotherapy. Korean J Intern Med. 2017;32(2):335-344.
10. The effect of the mixture of Rhynchosia Nulubilis and hydroponic-cultured Panax ginseng on stress-induced depression. Jokull Journal. 2016;66(3):306-317.
11. Protective Effect of Fomes Fomentarius in Water Immersion Restrain Stress (WIRS) Induced Gastric Injury in Rats. Jokull Journal. 2016;66(10):15-22.
12. Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits. Journal of Dental Sciences. 2017;12: 205e212.
13. In vitro and in vivo anti-leukemic effects of cladoloside C2 are mediated by activation of Fas/ceramide synthase 6/p38 kinase/c-Jun NH2-terminal kinase/ caspase-8. Oncotarget. 2017;9(1):495-511.
14. Correlation between the time elapsed after liposuction and the risk of fat embolism: An animal model. Arch Plast Surg. 2018;45(1):14-22.
15. T-Cell Immunoglobulin Mucin 3 Expression on Tumor Infiltrating Lymphocytes as a Positive Prognosticator in Triple-Negative Breast Cancer. J Breast Cancer 2018;21(4):406-414.

동서대학교 임상병리학과 학사
경희대학교 의과대학 기초의과학과(생화학&분자생물학) 석사
경희대학교 의과대학 기초의과학과(생화학&분자생물학) 박사

인제대학교 의과대학 생리학교실, 박사후연구원(Post-doc)
동서대학교 임상병리학과 강사
경남정보대학교 임상병리과 강사
부산임상병리사협회 학술부장

Effects of cisplatin on mitochondrial function and autophagy-related proteins in skeletal muscle of rats. Seo DY, Bae J. H, Zhang D, Song W, Kwak HB, Heo JW, Yun HR, Kim TN, Lee SH, Kim AH, Jeong DH, Kim HK, Han, J. BMB Rep. 2021 Nov 30; 54(11) 575-580.

Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression. Yun HR, Ahn SW, Seol B, Vasileva EA, Mishchenko NP, Fedoreyev SA, Han J, Ko KS, Rhee BD, Seol JE, Kim HK. Mar Drugs. 2021;19(11):622.

Echinochrome A Protects against Ultraviolet B-induced Photoaging by Lowering Collagen Degradation and Inflammatory Cell Infiltration in Hairless Mice. Seol JE, Ahn SW, Seol B, Yun HR, Park N, Kim HK, asileva EA, Mishchenko NP, Fedoreyev SA, Han J. Mar Drugs. 2021;19(10):550.

Palmitoyl Protein Thioesterase 1 Is Essential for Myogenic Autophagy of C2C12 Skeletal Myoblast. Yun HR, Jo YH, Kim J, Nguyen NNY, Shin Y, Kim SS and Choi TG. Front. Physiol. 2020, 15 October ,11, 1261. doi: org/10.3389/fphys.2020.569221. PMID: 33178040 (First-Author)

Roles of Autophagy in Oxidative Stress. Yun HR, Jo YH, Kim J, Shin Y, Kim SS, Choi TG. Int J Mol Sci. 2020 May6;21(9):E3289.

PAC-5 gene expression signature for predicting prognosis of patients with pancreatic adenocarcinoma. Kim J, Jo JH, Jang M, Nguyen NNY, Yun HR, Ko SH, Shin Y, Lee J-S, Kang I, Ha J, Choi TG and Kim SS. Cancers(Basel). 2019 Nov;7(11):1749.

Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy. Kim JH, Choi TG, Park S, Yun HR, Nguyen NNY, Jo YH, Jang M, Kim J, Kim J, Kang I, Ha J, Murphy MP, Tang DG, Kim SS. Cell Death Differ. 2018 Nov;25(11):1921-1937.

Cyclophilin B induces chemoresistance by degrading wild-type p53 via interaction with MDM2 in colorectal cancer. Choi TG, Nguyen MN, Kim J, Jo YH, Jang M, Nguyen NNY, Yun HR, Choe W, Kang I, Ha J, Tang DG, Kim SS. J Pathol. 2018 Sep;246(1):115-126.

An 8-gene signature for prediction of prognosis and chemoresponse in non-small cell lung cancer. Shahid M, Choi TG, Nguyen MN, Matondo A, Jo YH, Yoo JY, Nguyen NN, Yun HR, Kim J, Akter S, Kang I, Ha J, Maeng CH, Kim SY, Lee JS, Kim J, Kim SS. Oncotarget. 2016 Dec 27;7(52):86561-86572.

Prognostic value and their clinical implication of 89-gene signature in glioma. Shahid M, Cho KM, Nguyen MN, Choi TG, Jo YH, Aryal SN, Yoo JY, Yun HR, Lee JW, Eun YG, Lee JS, Kang I, Ha J, Yoon HJ, Kim SY, Kim SS. Oncotarget. 2016 Jun 13.