임상병리학과

고려대학교 생물학과 학사
고려대학교 생명공학과(분자미생물학) 석사
고려대학교 생명공학과(분자미생물학) 박사

미국 코넬대학교 미생물학과, 전임연구원(Research Associate)
미국 코넬대학교 미생물학과, 박사후연구원(Post-doc)
고려대학교 BK21생명공학원사업단 연구교수
세종대학교 시간강사
서울대학교 의과대학 암연구소(면역학) 연구원

-연구논문

Kim S, Lee YH. The Salmonella enterica EnvE is an Outer Membrane Lipoprotein and Its Gene Expression Leads to Transcriptional Repression of the Virulence Gene msgA. J Microbiol. 2024;62(11):1013-1022.

Kim S, Lee YH. Impact of small RNA RaoN on nitrosative-oxidative stress resistance and virulence of Salmonella enterica serovar Typhimurium. J Microbiol. 2020;58(6):499-506.

Lee YH, Kim JH. Direct interaction between the transcription factors CadC and OmpR involved in the acid stress response of Salmonella enterica. J Microbiol. 2017;55(12):966-972.

Kim BM, Hong Y, Lee S, Liu P, Lim JH, Lee YH, Lee TH, Chang KT, Hong Y. Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy. Int J Mol Sci. 2015;16(11):26880-26913.

Lee YH, Helmann JD. Mutations in the primary sigma factor σA and termination factor rho that reduce susceptibility to cell wall antibiotics. J Bacteriol. 2014;196(21):3700-3711.

Lee YH, Helmann JD. Reducing the Level of Undecaprenyl Pyrophosphate Synthase Has Complex Effects on Susceptibility to Cell Wall Antibiotics. Antimicrob Agents Chemother. 2013;57(9):4267-4275.

Lee YH, Kim S, Helmann JD, Kim BH, Park YK. RaoN, a small RNA encoded within Salmonella pathogenicity island-11, confers resistance to macrophage-induced stress. Microbiology(SGM). 2013;159(Pt 7):1366-1378.

Lee YH, Nam KH, Helmann JD. A mutation of the RNA polymerase β' subunit (rpoC) confers cephalosporin resistance in Bacillus subtilis. Antimicrob Agents Chemother. 2013;57(1):56-65.

Lee YH, Kim S, Kim JH, Bang IS, Lee IS, Bang SH, Park YK. A phosphotransferase system permease is a novel component of CadC signaling in Salmonella enterica. FEMS Microbiol Lett. 2013;338(1):54-61.

Lee YH, Kingston AW, Helmann JD. Glutamate dehydrogenase affects resistance to cell wall antibiotics in Bacillus subtilis. J Bacteriol. 2012;194(5):993-1001.

이화여자대학교(제약학), 학사
이화여자대학교(생약학), 석사
Rutgers-The State University of New Jersey(의약화학), Ph.D

동서대학교 총괄부총장(2019년~)
세계여성과학기술인네트워크(INWES) 회장(2021년~2023년)
세계여성과학기술인네트워크(INWES) 부회장(2017년~2020년)
동서대학교 제2부총장(2016년~2018년)
동서대학교 인사평가처장(2015년~2016년)
부산울산경남여성과학기술인지원센터(BIS-WIST) 센터장(2009년~2011년)
동서대학교 보건의료계열 학부장(2008년~2012년)

연구논문 (주요 연구논문)

1. 김보경, 강지은, 이승환, 김정선, Marion Abraham, Development of an Escherichia coli biofilm model on transwell, 대한임상검사학회지 (The Korean Journal of Clinical Laboratory Sciences) 44(3), 112-117 (2012).

2. NS Ma, M Abraham, MJ Choi, JS Kim, Skin permeation and comparative evaluation of gentisic acid ester derivatives as skin-lightening agents, J. Drug Del. Sci. Tech. 24(2) 212-217 (2014). _SCI

3. Jae-Young Lee, Jung Sun Kim, Hyon-Jong Cho, Dae-Duk Kim, Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery, International Journal of Nanomedicine 9, 2803-2813 (2014). _SCI

4. Eunjae Jung, Eun Young Lee, Hoo-Kyun Choi, Sang-Jun Ban, Seung-Hyuk Choi, Jung Sun Kim, In-Soo Yoon, Dae-Duk Kim, Development of drug-in-adhesive patch formulations for transdermal delivery of fluoxetine: in vitro and in vivo evaluations, Int. J. Pharm, 487, 49-55 (2015). _SCI

5. Dong-Hwan Kim, Alexander Jahn, Sung-Joon Choi, Jung Sun Kim, Min-Hyo Ki, Dae-Duk Kim, Lyotropic liquid crystal systems in drug delivery; a review, J. Pharm Invest , 45, 1-11 (2015).

6. Jae-Young Lee, Ubonvan Termsarasab, Mee Yeon Lee, Dong-Hwan Kim, Song Yi Lee, Jung Sun Kim, Hyon-Jong Cho, Dae-Duk Kim, Chemosensitizing indomethancin-conjugated chitosan oligosaccharide nanoparticles for tumor-targeted drug delivery, Acta Biomaterialia 57, 262-273 (2017). _SCI


여성과학기술인 정책 연구논문

1. 김정선, 부산울산경남여성과학기술인지원센터, Busan RHD Review, 3(3), 29-43 (2010).

2. 박혜영, 김정선, 엄미례, 동남권 여성과학기술인 육성 및 활용 현황, Busan RHD Review, 3(4), 14-22 (2010)

3. JS Kim & HY Park, Small Group Support: Attacting and Retaining Women in SET in Korea, International Journal of Gender, Science and Technology 6(2), 252-263 (2014).

4. 이공주복, 김정선, 2014 미래인재 균형개발을 위한 정책보고서, 대한여성과학기술인회, 미래창조과학부, ISSN 2383-8183 (2014)

5. 김정선, 김선정, 최경온, 아시아 여성과학기술인들의 유리천장: INWES APNN 회원국대상 공동설문 조사 결과, 대한여성과학기술인회, 미래창조과학부, ISSN 2383-8183 (2015)

6. 이공주복, 김정선, 김양희, 2016 미래인재 균형개발을 위한 정책보고서, 대한여성과학기술인회, 미래창조과학부, ISSN 2383-8183 (2016)

7. 김정선, 박혜영, 이공주복 2017 아시아태평양과학기술젠더장벽 정책 보고서, 대한여성과학기술인회, 과학기술정통부, ISSN 2383-8183 (2017)

8. 이공주복, 박혜영, 김정선, 김양희, 2018 미래인재 균형개발을 위한 정책보고서, 대한여성과학기술인회, 과학기술정통부, ISSN 2383-8183 (2018)

9. 김정선, 박혜영, 아시아태평양지역 과학기술분야 젠더장벽 인식조사 종합보고서 (2014-2018), ISSN 2714-0725 (2019)


특허(Patents):

1. LaVoie, E. J.; Kim, J. S.; Liu, L. F.; Heterocyclic topoisomerase poisons, United States Patent number: 6,667,302B2 (December 23, 2003)

2. 섬진이에스티, 김만종, 박성훈 (특허권자), 박성훈, 김정선, 서영완, 김유진, 김만종 (발명자), 특허 제 10-0777780호, 등록일 2007년 11월13일, 정족수 감지를 저해하는 항균제 조성물

저서 :

1. 김정선, 하경자, 하윤경, “과학이슈쟁점”, 엘컴퍼니, (2013) (ISBN 978-89-85597-35-7)

2. 윤은경, 김정선, 황주혜, 정수원, 이용규, 이상우, 홍정화, 김재정, 김분태 (2007), “여성과 진로: 진로선택과 진로 결정”, 공동체 (ISBN 978-89-91903-64-7).

3 정숙현, 이상우, 홍정화, 이용규, 김분태, 박성미, 김정선, 길임주, 김재정 (2007), “여성과 진로: 경력관리”, 공동체 (ISBN 978-89-92737-12-8).

역서 :

1. 권헌영, 김동운, 김정선, 도성탁, 류재두, 박화진, 이미화, 장철수, 정하승 (2009), 생화학 (Biochemistry) 三輪一智저, 정문각 (ISBN 978-89-7742-413-5)

2. 강영태, 김복조, 김윤식, 김정선, 김홍성, 이국성, 이미화, 이인수, 이은주, 이준호, 이혁재, 장철수, 정석률, 최명재 (2012), 임상화학(Clinical Chemistry) 제 6판, Bishop. Fodey and Schoeff 저, 바이오메디북 (ISBN 978-89-966590-0-6)

3. 화학교재연구회 (10인이상, 제9장 번역 감수) (2019) 팀버레이크의 대학화학기초 제5판, Karen Timberlake & William Timberlake, 사이플러스 (ISBN 979-11-88731-03-9)

수상

1. 과학기술훈장 웅비장 (3급) (과학기술정보통신부) (2019)

2. 한일코메드 학술상 (대한미생물검사학회 추계학술대회) (2013)

3. WISET 공로상 (한국연구재단 이사장) (2011)

4. 과학기술진흥유공자 국무총리표창 (교육과학기술부) (2011)

고려대학교(생물학), 학사
고려대학교(동물학), 석사
고려대학교(동물학), 박사

동서대학교 보건의료계열 학부장
동서대학교 보건의료계열 임상병리학과 책임교수
경희대학교 연구전임강사
고려대학교 연구조교수
제일약품 주식회사 신약연구실 책임연구원

* 논문

주요우울장애의 발병률에 미치는 성의 영향, 스트레스연구, 21, 167-174, 2013

Neuroprotective Effects of α-Tocotrienol on Kainic Acid-Induced Neurotoxicity in Organotypic Hippocampal Slice Cultures, International Journal of Molecular Sciences, 14, 18256-18268, 2013

주요우울장애와 생물표지자, 스트레스연구, 20, 247-255, 2012

혈소판의 기능 측정방법과 그 활용, 응용미약에너지학회지, 10, 1-4, 2012

Effects of Electroacupuncture at BL60 on Formalin-Induced Pain in Rats, Evidence-Based Complementary and Alternative Medicine, 2012, 797-807, 2012

Coenzyme Q10 protects neurons against neurotoxicity in hippocampal slice culture, Neuroreport, 22, 96-107, 2011

Optical imaging of somatosensory evoked potentials in the rat cerebral cortex after spinal cord injury, Journal of Neurotrauma, 28, 1-5, 2011

Inhibition of hexokinase leads to neuroprotection against excitotoxicity in organotypic hippocampal slice culture, Journal of Neuroscience Research, 89, 551-558, 2011

Neuroprotective effects of FK506 against excitotoxicity in organotypic hippocampal slice culture, Neuroscience Letters, 474, 126-130, 2010

통증, 침술 및 뇌영상, 감성과학, 13, 551-558, 2010

신경병리성 동통과 교차-철회 반사, 응용미약자기에너지학회지, 7, 22-26, 2009

Relationship between diet composition and the fecundity of Musca domestica, Entomological Research, 39, 412-415, 2009

Reproducibility and desensitization of the power frequency magnetic field effect
on movement of the common cutworm Spodoptera litura, Entomological Research, 39, 406-409, 2009

Cloning and blood-meal dependent induction pattern of apolipophorin-III from Anopheles sinensis, Entomological Research, 39, 388-393, 2009

Modulation of Neuropathic Pain by Galanin and Neuropeptide Y at the Level of
the Medulla in Rats, International Journal of Neuroscience, 119, 1941-1955, 2009

Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures, Can. J. Physiol. Pharmacol, 87, 440-447, 2009

Anti-oxidant effet of ascorbic and dehydroascorbic acids in hippocalmpal slice culture, Biochemical and Biophysical Research Communications, 366, 8-14, 2008

경성대학교 화학과 학사
경성대학교 생화학과 석사

침례병원 진단검사의학과, 실장(부장)
現 동방메디칼(주), 이사
現 진주보건대학교, 겸임교수
現 동의대학교, 외래교수
現 부산임상병리사 협회, 자문위원

ㆍ부산가톨릭대학교(임상병리학), 학사
ㆍ부산가톨릭대학교(임상병리학), 석사
ㆍ동아대학교 의학과(병리학), 박사

ㆍ부산가톨릭대학교 임상병리학과 학사조교
ㆍ동아대학교 의과대학 병리학교실 전임연구원
ㆍ동의대학교 임상병리학과 시간강사
ㆍ동서대학교 임상병리학과 시간강사

- 연구논문 (최근 5년) -
1. Potential ameliorative effects of anion generator in rat with adjuvant-induced arthritis. The Asian International Journal of Life Sciences. 2014;10:75-87.
2. The Effect of Berchemia berchemiaefolia Extract in a Rat Model Acetic Acid-induced Irritable Bowel Syndrome. International Journal of Bio-Science and Bio-Technology. 2014;.6(5):67-82.
3. DNA ligase4 as a prognostic marker in nasopharyngeal cancer patients treated with radiotherapy. Asian Pac J Cancer Prev. 2014;15(24):10985-9.
4. Targeted anticancer effect through microRNA-181a regulated tumor-specific hTERT replacement. Cancer Lett. 2015;356(2 Pt B):918-28.
5. The Influence of Korean Berchemia berchemiaefolia (Makino) Koidz Extract on Nonalcoholic Hepatic Steatosis in Rats. Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology. 2015;5(3):131-142.
6. Targeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA Regulation. Sci Rep. 2015;5:12315.
7. By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, stichoposide D inhibits growth of leukemia xenografts. Oncotarget. 2015;6(29):27596-612.
8. Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma. Theranostics. 2016;6(3):357-68.
9. Clinicopathologic significance of tumor microenvironment CD11c, and FOXP3 expression in diffuse large B-cell lymphoma patients receiving rituximab, cyclophosphamide, anthracycline, vincristine, and prednisone (R-CHOP) combination chemotherapy. Korean J Intern Med. 2017;32(2):335-344.
10. The effect of the mixture of Rhynchosia Nulubilis and hydroponic-cultured Panax ginseng on stress-induced depression. Jokull Journal. 2016;66(3):306-317.
11. Protective Effect of Fomes Fomentarius in Water Immersion Restrain Stress (WIRS) Induced Gastric Injury in Rats. Jokull Journal. 2016;66(10):15-22.
12. Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits. Journal of Dental Sciences. 2017;12: 205e212.
13. In vitro and in vivo anti-leukemic effects of cladoloside C2 are mediated by activation of Fas/ceramide synthase 6/p38 kinase/c-Jun NH2-terminal kinase/ caspase-8. Oncotarget. 2017;9(1):495-511.
14. Correlation between the time elapsed after liposuction and the risk of fat embolism: An animal model. Arch Plast Surg. 2018;45(1):14-22.
15. T-Cell Immunoglobulin Mucin 3 Expression on Tumor Infiltrating Lymphocytes as a Positive Prognosticator in Triple-Negative Breast Cancer. J Breast Cancer 2018;21(4):406-414.

동서대학교 임상병리학과 학사
경희대학교 의과대학 기초의과학과(생화학&분자생물학) 석사
경희대학교 의과대학 기초의과학과(생화학&분자생물학) 박사

인제대학교 의과대학 생리학교실, 박사후연구원(Post-doc)
동서대학교 시간강사
경남정보대학교 시간강사
부산임상병리사협회 학술부장

Effects of cisplatin on mitochondrial function and autophagy-related proteins in skeletal muscle of rats. Seo DY, Bae J. H, Zhang D, Song W, Kwak HB, Heo JW, Yun HR, Kim TN, Lee SH, Kim AH, Jeong DH, Kim HK, Han, J. BMB Rep. 2021 Nov 30; 54(11) 575-580.

Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression. Yun HR, Ahn SW, Seol B, Vasileva EA, Mishchenko NP, Fedoreyev SA, Han J, Ko KS, Rhee BD, Seol JE, Kim HK. Mar Drugs. 2021;19(11):622.

Echinochrome A Protects against Ultraviolet B-induced Photoaging by Lowering Collagen Degradation and Inflammatory Cell Infiltration in Hairless Mice. Seol JE, Ahn SW, Seol B, Yun HR, Park N, Kim HK, asileva EA, Mishchenko NP, Fedoreyev SA, Han J. Mar Drugs. 2021;19(10):550.

Palmitoyl Protein Thioesterase 1 Is Essential for Myogenic Autophagy of C2C12 Skeletal Myoblast. Yun HR, Jo YH, Kim J, Nguyen NNY, Shin Y, Kim SS and Choi TG. Front. Physiol. 2020, 15 October ,11, 1261. doi: org/10.3389/fphys.2020.569221. PMID: 33178040 (First-Author)

Roles of Autophagy in Oxidative Stress. Yun HR, Jo YH, Kim J, Shin Y, Kim SS, Choi TG. Int J Mol Sci. 2020 May6;21(9):E3289.

PAC-5 gene expression signature for predicting prognosis of patients with pancreatic adenocarcinoma. Kim J, Jo JH, Jang M, Nguyen NNY, Yun HR, Ko SH, Shin Y, Lee J-S, Kang I, Ha J, Choi TG and Kim SS. Cancers(Basel). 2019 Nov;7(11):1749.

Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy. Kim JH, Choi TG, Park S, Yun HR, Nguyen NNY, Jo YH, Jang M, Kim J, Kim J, Kang I, Ha J, Murphy MP, Tang DG, Kim SS. Cell Death Differ. 2018 Nov;25(11):1921-1937.

Cyclophilin B induces chemoresistance by degrading wild-type p53 via interaction with MDM2 in colorectal cancer. Choi TG, Nguyen MN, Kim J, Jo YH, Jang M, Nguyen NNY, Yun HR, Choe W, Kang I, Ha J, Tang DG, Kim SS. J Pathol. 2018 Sep;246(1):115-126.

An 8-gene signature for prediction of prognosis and chemoresponse in non-small cell lung cancer. Shahid M, Choi TG, Nguyen MN, Matondo A, Jo YH, Yoo JY, Nguyen NN, Yun HR, Kim J, Akter S, Kang I, Ha J, Maeng CH, Kim SY, Lee JS, Kim J, Kim SS. Oncotarget. 2016 Dec 27;7(52):86561-86572.

Prognostic value and their clinical implication of 89-gene signature in glioma. Shahid M, Cho KM, Nguyen MN, Choi TG, Jo YH, Aryal SN, Yoo JY, Yun HR, Lee JW, Eun YG, Lee JS, Kang I, Ha J, Yoon HJ, Kim SY, Kim SS. Oncotarget. 2016 Jun 13.